Publication
2024
Lipid radicals and oxidized cholesteryl esters in low- and high-density lipoproteins in patients with β-thalassemia: Effects of iron overload and iron chelation therapy
Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Luechapudiporn R, Yamada KI, Morales NPFree Radic Biol Med. 18:224:618-629, 2024
The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium-Glucose Transporter 2 Inhibitors.
Yamato M, Kato N, Yamada KI, Inoguchi TDiabetes. db220970, 2024
Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases
Mori R, Abe M, Saimoto Y, Shinto S, Jodai S, Tomomatsu M, Tazoe K, Ishida M, Enoki M, Kato M, Yamashita T, Itabashi Y, Nakanishi I, Ohkubo K, Kaidzu S, Tanito M, Matsuoka Y, Morimoto K, Yamada KIRedox Biol. 73:103186, 2024
Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation
Tsuruta K, Matsuoka M, Harada S, Enomoto A, Kumagai T, Yasuda S, Koumura T, Yamada KI, Imai HJ Clin Biochem Nutr. 74,97-107, 2024
Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells
Tomomatsu M, Imamura N, Izumi H, Watanabe M, Ikeda M, Ide T, Uchinomiya S, Ojida A, Jutanom M, Morimoto K, Yamada KIBiol Pharm Bull. 47(3),641-651,2024
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi MNat Commun. 15(1):2195, 2024
Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice.
Ueno M, Shibata S, Nakanishi I, Aoki I, Yamada KI, Matsumoto KI.J Clin Biochem Nutr. 72(2):107-116, 2023
Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A.
Ishimaru K, Ikeda M, Miyamoto HD, Furusawa S, Abe K, Watanabe M, Kanamura T, Fujita S, Nishimura R, Toyohara T, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H, Ide TJ Am Heart Assoc. 13(1):e031219, 2024
Ethoxyquin a Lipid Peroxidation Inhibitor Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion.
Abe M, Sou M, Matsuoka Y, Morimoto K, Yamada KI.Biol Pharm Bull. 47(1):104-111, 2024
Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice
Bo T, Nohara H, Yamada K, Miyata S, Fujii J.Antioxidants 13(2), 2024
2023
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.JCI Insight. 8(6):e169756, 2023
Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage.
Fujii J, Yamada KI.Free Radic Res. 57(5):353-372, 2023
MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion.
Ichihara G, Katsumata Y, Sugiura Y, Matsuoka Y, Maeda R, Endo J, Anzai A, Shirakawa K, Moriyama H, Kitakata H, Hiraide T, Goto S, Ko S, Iwasawa Y, Sugai K, Daigo K, Goto S, Sato K, Yamada KI, Suematsu M, Ieda M, Sano M.Circ Res. 133(10):861-876, 2023
Structural Analysis of Intracellular Lipid Radicals by LC/MS/MS Using a BODIPY-Based Profluorescent Nitroxide Probe
Udo T, Matsuoka Y, Takahashi M, Izumi Y, Saito K, Tazoe K, Tanaka M, Naka H, Bamba T, Yamada KIAnal. Chem 95,10, 4585-4591, 2023
Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis
Saito K, Matsuoka Y, Abe M, Kato N, Morimoto K, Yamada KIRedox Ex Med. e220024, 2023
2022
SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Lee B, An HJ, Kim DH, Lee MK, Jeong HH, Chung KW, Go Y, Seo AY, Kim IY, Seong JK, Yu BP, Lee J, Im E, Lee IK, Lee MS, Yamada KI, Chung HYExp Mol Med. ;54(11):2036-2046, 2022
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis
Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui HSci Signal. 15(758):eabn8017,2022
Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity
Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui HJ Cardiovasc Pharmacol 80(5):690-699,2022
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão AASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M.Nature. 608(7924):778-783,2022
Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe
Yamauchi K, Matsuoka Y, Takahashi M, Izumi Y, Naka H, Taniguchi Y, Kawai K, Bamba T, Yamada KI.Chem Commun. 58,56-59, 2022
Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury
Miyamoto DH, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K, Imai H, Tsutsui HJACC Basic Transl Sci. 27,7(8),800-819,2022
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Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol
Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Leuchapudiporn R, Yamada KI, Morales NPBiomed Pharmacother. 154:113624,2022
2021
Three-dimensional electron paramagnetic resonance imaging of mice using ascorbic acid sensitive nitroxide imaging probes.
Sato-Akaba H, Emoto MC, Yamada KI, Koshino H, Fujii HGFree Radic Res. 55(9-10):950-957, 2021
Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe
Yamauchi K, Matsuoka Y, Takahashi M, Izumi Y, Naka H, Taniguchi Y, Kawai K, Bamba T, Yamada KI.Chem Commun. 1, 2022
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada KI.Nat Commun. 12, 6339, 2021
Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol
Anegawa D, Sugiura Y, Matsuoka Y, Sone M, Shichiri M, Otsuka R, Ishida N, Yamada KI, Suematsu M, Miura M, Yamaguchi Y.Commun Biol. 4,796, 2021
Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.
Ishii N, Homma T, Takeda Y, Aung NY, Yamada KI, Miyata S, Asao H, Yamakawa M, Fujii J.J Nutr Biochem. 91:108604, 2021
Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T.Free Radic Biol Med, 162:255-265, 2021.
A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals.
Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.Free Radic Biol Med. 163:297-305, 2021
Push-Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity-Induced Aggregation and Crystallization-Induced Emission Enhancement and Fluorescence Resonance Energy Transfer.
Hagihara R, Umeno T, Ueki S, Yoshihara D, Fuchi Y, Usui K, Sakuma M, Yamada KI, Karasawa S.Chemistry. 27(9):3039-3046, 2021.
Detection and structural analysis of lipid-derived radicals in vitro and in vivo.
Matsuoka Y, Yamada KI.Free Radic Res. 8:1-9, 2021.
2020
Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes.
Yamato M, Kato N, Kakino A, Yamada KI, Inoguchi T.Metabol Open. 7:100049, 2020
Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice.
Ishii N, Homma T, Guo X, Yamada KI, Yamada S, Fujii JToxicol Lett. 333:192-201, 2020
Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach.
Shiraishi R, Matsumoto S, Fuchi Y, Naganuma T, Yoshihara D, Usui K, Yamada KI, Karasawa S.Langmuir. 36-19:5280-5286,2020
Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice.
Moon G, Kobayashi S, Aung Naing Y, Yamada KI, Yamakawa M, Fujii J.Free Radic Res. 54(8-9):606-619,2020
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.JCI Insight. 5:9, 2020
Reaction Targets of Antioxidants in Azo-Initiator or Lipid Hydroperoxide Induced Lipid Peroxidation.
Saito K, Matsuoka Y, Yamada KI.Free Radic Res. 26:1-23,2020
Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.
Takahashi M, Homma T, Yamada KI, Miyata S, Nakajima O, Fujii J.LIFE SCI. 249:117501, 2020
Method for Structural Determination of Lipid-Derived Radicals.
Matsuoka Y, Izumi Y, Takahashi M, Bamba T, Yamada KI.Anal Chem. 2020
2019
Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals.
Yamasaki T, Azuma R, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.ACS Med Chem Lett. 11(1):45-48. 2019
Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents.
Shiraishi R, Kaneko T, Usui K, Naganuma T, Iizuka N, Morishita K, Kobayashi S, Fuchi Y, Matsuoka Y, Hirai G, Yamada KI, Karasawa S.ACS Omega. 22;4(24):20715-20723, 2019
Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice.
Ishii N, Homma T, Lee J, Mitsuhashi H, Yamada KI, Kimura N, Yamamoto Y, Fujii J.Biol Reprod. ioz149,1-14,2019.
Radiation-induced redox alteration in the mouse brain.
Nakamura M, Yamasaki T, Ueno M, Shibata S, Ozawa Y, Kamada T, Nakanishi I, Yamada KI, Aoki I, Matsumoto KI.Free Radic Biol Med. 22;143:412-421, 2019.
Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice.
Kurihara,K, Homma T, Kobayashi S, Shichiri M, Fujiwara H, Fujii S, Yamada KI, Nakane M, Kawamae K, Fujii J.J Clin Biochem Nutr. 65(2):1-8, 2019
2-Oxo-histidine-containing dipeptides are functional oxidation products.
Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamada KI, Uchida K.J Biol Chem. 25;294(4):1279-1289, 2019
2018
Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model
Emoto MC, Sato-Akaba H, Matsuoka Y, Yamada KI, Fujii HG.Neurosci Lett. 690:6-10, 2018
Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative.
Araki T, Fuchi Y, Murayama S, Shiraishi R, Oyama T, Aso M, Aoki I, Kobayashi S, Yamada KI, Karasawa S.Nanomaterials. 2;8(10), 2018
Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury
Homma T, Shirato T, Akihara R, Kobayashi S, Lee J, Yamada KI, Miyata S, Takahashi M, Fujii J.Toxicol Lett. 690:6-10, 2018
Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.
Fujita A, Yamaguchi H, Yamasaki R, Cui Y, Matsuoka Y, Yamada KI, Kira JI.J Neuroinflammation. 13;15(1):227, 2018
Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells.
Yamamoto K, Yasui H, Bo T, Yamamori T, Hiraoka W, Yamasaki T, Yamada KI, Inanami O.Appl Magn Reson. 49(8):837-851, 2018
In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging.
Yasukawa K, Shigemi R, Kanbe T, Mutsumoto Y, Oda F, Ichikawa K, Yamada KI, Tun X, Utsumi H.JAntioxid Redox Signal. 2018
Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice.
Kato N, Sato S, Yamada KI, Ichikawa K.Appl Magn Reson. 49(8)869-879, 2018
Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death
Shinto S, Matsuoka Y, Yamato M Yamada KI.J Clin Biochem Nutr. 62(2):132-138, 2018
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis.
Tun X, Yasukawa K, Yamada KI.J Biol Pharm Bull. 41(12):1843-1852, 2018
2017
Detection and inhibition of lipid-derived radicals in low-density lipoprotein.
Ishida Y, Okamoto Y, Matsuoka Y, Tada A, Janprasit J, Yamato M, Morales NP, Yamada KI.Free Radical Biol. Med. 113,487-493,2017
Lipid radicals cause light-induced retinal degeneration.
Enoki M, Shinto S, Matsuoka Y, Otsuka A, Kaidzu S, Tanito M, Shibata T, Uchida K, Ohira A, Yamato M, Yamada KI.Chem. Commun. 53,10922-10925,2017
Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T.
Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto K, Kamada T, Yamada KI, Aoki I.Am J Transl Res. 9(10):4481-4491, 2017.
Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging.
Emoto MC, Matsuoka Y, Yamada KI, Sato-Akaba H, Fujii HG.Biochem Biophys Res Commun. 2017 Apr 15;485(4):802-806 Epub 2017 Feb 28.
Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells
Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T, Yamasaki T, Yamada K, Inanami O.Cancer Lett. 2017 Jan ;390:160-167.
2016
Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
Akihara R, Homma T, Lee J, Yamada KI, Miyata S, Fujii J.Behav. Brain Res. 478;2:765-771,2016.
Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)
Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada KI, Miyata S, Nakajima O, Fujii J.Behav Brain Res. 2016 Nov 22;319:219-224.
Fluorescence probes to detect lipid-derived radicals.
Yamada K, Mito F, Matsuoka Y, Ide S, Shikimachi K, Fujiki A, Kusakabe D, Ishida Y, Enoki M, Tada A, Ariyoshi M, Yamasaki T, Yamato M.Nat Chem Biol. 2016 Aug;12(8):608-13.
Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.
Kurahashi T, Lee J, Nabeshima A, Homma T, Kang ES, Saito Y, Yamada S, Nakayama T, Yamada KI, Miyata S, Fujii J.Arch Biochem Biophys. 604:36-46, 2016.
A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma.
Matsuoka Y, Ohkubo K, Yamasaki T, Yamato M, Ohtabu H, Shirouzu T, Fukuzumi S, Yamada K.RSC Advances. 58(1):16-22, 2016.
TEMPOL increases NAD+ and improves redox imbalance in obese mice.
Yamato M, Kawano K, Yamanaka Y, Saiga M, Yamada KI.Redox Biol. 8:316-322, 2016.
Photodecomposition of tetrabromobisphenol A in aqueous humic acid suspension by irradiation with light of various wavelengths.
Han SK, Yamasaki T, Yamada K.Chemosphere. 147:124-30, 2016.
A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats.
Kimura S, Inoguchi T, Yamasaki T, Yamato M, Ide M, Sonoda N, Yamada K, Takayanagi R.Metabolism. 65(3): 138-145, 2016.
Fluorescence probe for the convenient and sensitive detection of ascorbic acid.
Matsuoka Y, Yamato M, Yamada K.J. Clin. Biochem. Nutr. 58(1):16-22, 2016.
2015
Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe.
Emoto MC, Yamato M, Akaba-Sato H, Yamada K, *Fujii HG.Neurosci Lett. 608:40-44, 2015.
Brain Contrasting Ability of Blood-Brain-Barrier- Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging.
Matsumoto K, Yamasaki T, Nakamura M, Ueno M, Nakanishi I, Shibata S, Sekita A, Saga T, Kamada T, Yamada K, Aoki I.Magn Reson Med. DOI: 10.1002/mrm.25918,2015
Brain Imaging in Methamphetamine-Treated Mice using a Nitroxide Contrast Agent for EPR Imaging of the Redox Status and a Gadolinium Contrast Agent for MRI Observation of Blood-Brain Barrier Function.
Emoto MC, Yamato M, Akaba-Sato H, Yamada KI, Matsuoka Y, Fujii HG.Free Radic Res. 49(8):1038-1047, 2015
Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress.
Ikeda M, Ide T, Fujino T, Arai S, Saku K, Kakino T, Tyynismaa H, Yamasaki T, Yamada K, Kang D, Suomalainen A, Sunagawa K.PLoS One. 10(3):e0119687, 2015. doi:10.1371/journal. pone.0119687.
2014
Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis.
Tun X, Yasukawa K, Yamada K.Free Radic Biol Med. 2014 Sep;74:108-17. doi: 10.1016/j.freeradbiomed.2014.06.020. Epub 2014 Jun 30.
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides
Kajer TB, Fairfull-Smith KE, Yamasaki T, Yamada KI, Fu S, Bottle SE, Hawkins CL, Davies MJ.Free Radic Biol Med. 70:96-105, 2014.
Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Kurahashi T, Kwon M, Homma T, Saito Y, Lee J, Takahashi M, Yamada KI, Miyata S, Fujii J.Biochem Biophys Res Commun. 452(1):136-41, 2014.
Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction.
Yamato M, Ishimatsu A, Yamanaka Y, Mine T, Yamada K.J Clin Biochem Nutr. 55(1):11-14, 2014.
Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice.
Ito J, Otsuki N, Zhang X, Konno T, Kurahashi T, Takahashi M, Yamato M, Matsuoka Y, Yamada K, Miyata S, Fujii J.Life Sci. 95(1):1-8, 2014.
Change in Overhauser Effect-Enhaced MRI Signal in Response to uPA Highly Expressing in Tumor.
Niidome T, Chijiiwa N, Yamasaki T, Yamada K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayama YChem Lett. 43:999-1001, 2014.
Diffusion Studies of Redox-Sensitive Nitroxyl Spin Probes through Bilayer Lipid Membranes using 300 MHz Electron Spin Resonance Spectrometer.
Dhas MK, Utsumi H, Ichikawa K, Yamada K, Hyodo F, Jawahar A, Benial AMF.Eur J Acad Essays. 1(3):70-75, 2014.
2013
Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents.
Emoto M, Yamada KI, Yamato M, Fujii H.Neurosci Lett. 2013 May 2 [Epub ahead of print])
2012
Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch.
Matsuoka Y, Yamato M, Yamasaki T, Mito F and Yamada KI.Free Radic Biol Med. 2012 Dec 1;53(11):2112-8. doi: 10.1016/j.freeradbiomed.2012.09.032. Epub 2012 Sep 28.
The detrimental effect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis.
Yasukawa K, Tokuda H, Tun X, Utsumi H and Yamada KI.Free Radic Res. 2012 Dec;46(12):1427-36. doi: 10.3109/10715762.2012.732698. Epub 2012 Oct 9.
Synthesis and Utilization of α-Substituted Nitroxides.
Yamasaki T, Mito F, Matsuoka Y, Yamato M and Yamada KI.(Book Chapter)in Nitroxides – Theory, Experiment and Applications Intech. 2012 Sep 12 [online] doi: 10.5772/39163
Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer.
A. Milton Franklin Benial, M. Kumara Dhas, Ichikawa K, Yamada KI, Hyodo F, Jawahar A. and Utsumi H.Appl Magn Reson. 2012 Aug 2 [Epub ahead of print]
Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI.
Kosem N, Naganuma T, Ichikawa K, Phumala Morales N, Yasukawa K, Hyodo F, Yamada K, Utsumi H.Free Radic Biol Med. 2012 Jul 15;53(2):328-36. doi: 10.1016/j.freeradbiomed.2012.04.026. Epub 2012 Apr 30.
High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice.
Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada KI, Kinugawa S, Tsutsui H.Mol Cell Biochem. 2012 Jan;359(1-2):161-7. doi: 10.1007/s11010-011-1010-3. Epub 2011 Aug 18.
2011
Redox Potential of Nitroxides is an Index to Evaluate Superoxide Dismutase Mimic Activity.
Yamasaki T, Matsuoka Y, Mito F, Yamato M, Yamada KI.Asian J Org Chem. 2013 May 10 (2013 Mar 7 [Epub ahead of print])
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease.
Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.Neuromolecular Med. 2013 Jun;15(2):238-51. doi: 10.1007/s12017-012-8214-x. Epub 2013 Jan 5.
Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.
Deguchi H, Yasukawa K, Yamasaki T, Mito F, Kinoshita Y, Naganuma T, Sato S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada KI.Free Radic Biol Med. 2011 Nov 1;51(9):1799-805. Epub 2011 Aug 18.
A novel ascorbic acid-resistive nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse.
Emoto M, Mito F, Yamasaki T, Yamada KI, Sato-Akaba H, Hirata H, Fujii H.Free Radic Res. 2011 Nov;45(11-12):1325-32. Epub 2011 Sep 26.
Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model.
Yamato M, Shiba T, Naganuma T, Ichikawa K, Utsumi H, Yamada KI.Neurochem Int. 2011 Nov;59(6):804-11. Epub 2011 Aug 17.
Oxygen cconcentration dependence of lipid peroxidation and lipid-derived radical generation: Application of profluorescent nitroxide switch.
Mito F, Kitagawa K, Yamasaki T, Shirahama C, Oishi T, Ito Y, Yamato M, Yamada K.Free Radic Res. 2011 Sep;45(9):1103-10.
In vivo imaging of mitochondrial function in methamphetamine-treated rats.
Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada K.NeuroImage. 2011 Aug 1;57(3):866-72.
Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.
Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S.Schizophr Res. 2011 Jul;129(2-3):172-82.
Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects.
Yamato M, Shiba T, Ide T, Honda Y, Yamada KI, Tsutsui H.Hypertens Res. 2011 Jul;34(7):840-5.
Structural concept of nitroxide as a lipid peroxidation inhibitor.
Yamasaki T, Ito Y, Mito F, Kitagawa K, Matsuoka Y, Yamato M, Yamada KI.J. Org. Chem. 2011 April 18;76(10):4144-8
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
Mito F, Yamasaki T, Ito Y, Yamato M, Mino H, Sadasue H, Shirahama C, Sakai K, Utsumi H, Yamada KI.Chem Commun (Camb). 2011 May 7;47(17):5070-2
Structure−reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies.
Yamasaki T, Mito F, Ito Y, Pandian S, Kinoshita Y, Nakano K, Murugesan R, Sakai K, Utsumi H, Yamada K.J. Org. Chem. 2011 Jan 21;76(2):435-40.