The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium-Glucose Transporter 2 Inhibitors. Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice. Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage. MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion. Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A. Ethoxyquin a Lipid Peroxidation Inhibitor Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion. Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice Three-dimensional electron paramagnetic resonance imaging of mice using ascorbic acid sensitive nitroxide imaging probes. Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes. Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice. Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals. Structural Analysis of Intracellular Lipid Radicals by LC/MS/MS Using a BODIPY-Based Profluorescent Nitroxide Probe Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach. Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels. Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue. A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals. Push-Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity-Induced Aggregation and Crystallization-Induced Emission Enhancement and Fluorescence Resonance Energy Transfer. Detection and structural analysis of lipid-derived radicals in vitro and in vivo. Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. Reaction Targets of Antioxidants in Azo-Initiator or Lipid Hydroperoxide Induced Lipid Peroxidation. Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway. Method for Structural Determination of Lipid-Derived Radicals. Kinetics and localization of hemin-induced lipoprotein oxidation. Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents. Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice. Radiation-induced redox alteration in the mouse brain. Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice. 2-Oxo-histidine-containing dipeptides are functional oxidation products. Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative. Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model. Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells. In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging. Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice. Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis. Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Lipid radicals cause light-induced retinal degeneration. Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T. Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging. Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress. Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a) Fluorescence probes to detect lipid-derived radicals. Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy. A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma. TEMPOL increases NAD+ and improves redox imbalance in obese mice. Photodecomposition of tetrabromobisphenol A in aqueous humic acid suspension by irradiation with light of various wavelengths. A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats. Fluorescence probe for the convenient and sensitive detection of ascorbic acid. Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe. Brain Contrasting Ability of Blood-Brain-Barrier- Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging. Brain Imaging in Methamphetamine-Treated Mice using a Nitroxide Contrast Agent for EPR Imaging of the Redox Status and a Gadolinium Contrast Agent for MRI Observation of Blood-Brain Barrier Function. Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress. Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction. Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. Change in Overhauser Effect-Enhaced MRI Signal in Response to uPA Highly Expressing in Tumor. Diffusion Studies of Redox-Sensitive Nitroxyl Spin Probes through Bilayer Lipid Membranes using 300 MHz Electron Spin Resonance Spectrometer. Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents. Redox Potential of Nitroxides is an Index to Evaluate Superoxide Dismutase Mimic Activity. A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease. Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch. The detrimental effect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis. Synthesis and Utilization of α-Substituted Nitroxides. Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer. Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI. High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice. Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. A novel ascorbic acid-resistive nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse. Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model. Oxygen cconcentration dependence of lipid peroxidation and lipid-derived radical generation: Application of profluorescent nitroxide switch. In vivo imaging of mitochondrial function in methamphetamine-treated rats. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia. Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects. Structural concept of nitroxide as a lipid peroxidation inhibitor. Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical. Structure−reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies.