{"id":488,"date":"2020-09-03T07:06:55","date_gmt":"2020-09-03T07:06:55","guid":{"rendered":"https:\/\/bukka.phar.kyushu-u.ac.jp\/?page_id=488"},"modified":"2020-12-24T17:18:27","modified_gmt":"2020-12-24T17:18:27","slug":"research","status":"publish","type":"page","link":"https:\/\/bukka.phar.kyushu-u.ac.jp\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n

1\uff09Development of detection and structural analysis technology for oxidized lipids<\/strong><\/h2>\n\n\n\n

Unsaturated fatty acids are easily oxidized. Therefore, oxidized lipids have also been thought to be a by-product of mere oxidative damage. However, it has recently been reported that these oxidized lipids and their metabolites act as causative molecules of various diseases and inflammations. However, the technology to measure these oxidized lipids specifically and with high sensitivity was limited.
When lipids are oxidized, lipid radicals, peroxides, and aldehydes are produced. Therefore, we first developed a probe for detecting lipid radicals ( Nat Chem Biol,<\/em> 2016<\/a> ). It is designed to fluoresce by trapping lipid radicals. In fact, in a model of chemical carcinogenesis and light-induced retinopathy ( Chem Commun,<\/em> 2017<\/a> ), we reported that lipid radicals were generated according to the symptoms. Recently, we are developing the structure analysis technology of these lipid radicals, and the detection and structure analysis technology of aldehydes. We plan to develop these technologies into biomarker searches using patient samples.<\/p>\n\n\n\n