Publication

2023

2022

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.

Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
Sci Signal. 15(758):eabn8017.

Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity

Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
J Cardiovasc Pharmacol. 1;80(5):690-699.

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão AASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M.
Nature. 608(7924):778-783,2022

Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol

Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Leuchapudiporn R, Yamada KI, Morales NP.
Biomed Pharmacother. 154:113624,2022.

Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury

Miyamoto DH, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K, Imai H, Tsutsui H.

Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe

Yamauchi K, Matsuoka Y, Takahashi M, Izumi Y, Naka H, Taniguchi Y, Kawai K, Bamba T, Yamada KI.
Chem Commun. 1, 2022

2021

Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada KI.
Nat Commun. 12, 6339, 2021

Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

Anegawa D, Sugiura Y, Matsuoka Y, Sone M, Shichiri M, Otsuka R, Ishida N, Yamada KI, Suematsu M, Miura M, Yamaguchi Y.
Commun Biol. 4,796, 2021

Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.

Ishii N, Homma T, Takeda Y, Aung NY, Yamada KI, Miyata S, Asao H, Yamakawa M, Fujii J.
J Nutr Biochem. 91:108604, 2021

Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.

Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T.
Free Radic Biol Med, 162:255-265, 2021.

A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals.

Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.
Free Radic Biol Med. 163:297-305, 2021

Push-Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity-Induced Aggregation and Crystallization-Induced Emission Enhancement and Fluorescence Resonance Energy Transfer.

Hagihara R, Umeno T, Ueki S, Yoshihara D, Fuchi Y, Usui K, Sakuma M, Yamada KI, Karasawa S.
Chemistry. 27(9):3039-3046, 2021.

Detection and structural analysis of lipid-derived radicals in vitro and in vivo.

Matsuoka Y, Yamada KI.
Free Radic Res. 8:1-9, 2021.

2020

Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach.

Shiraishi R, Matsumoto S, Fuchi Y, Naganuma T, Yoshihara D, Usui K, Yamada KI, Karasawa S.
Langmuir. 36-19:5280-5286,2020

Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice.

Moon G, Kobayashi S, Aung Naing Y, Yamada KI, Yamakawa M, Fujii J.
Free Radic Res. 54(8-9):606-619,2020

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.

Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
JCI Insight. 5:9, 2020

Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.

Takahashi M, Homma T, Yamada KI, Miyata S, Nakajima O, Fujii J.
LIFE SCI. 249:117501, 2020

Method for Structural Determination of Lipid-Derived Radicals.

Matsuoka Y, Izumi Y, Takahashi M, Bamba T, Yamada KI.
Anal Chem. 2020

2019

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents.

Shiraishi R, Kaneko T, Usui K, Naganuma T, Iizuka N, Morishita K, Kobayashi S, Fuchi Y, Matsuoka Y, Hirai G, Yamada KI, Karasawa S.
ACS Omega. 22;4(24):20715-20723, 2019

Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice.

Ishii N, Homma T, Lee J, Mitsuhashi H, Yamada KI, Kimura N, Yamamoto Y, Fujii J.
Biol Reprod. ioz149,1-14,2019.

Radiation-induced redox alteration in the mouse brain.

Nakamura M, Yamasaki T, Ueno M, Shibata S, Ozawa Y, Kamada T, Nakanishi I, Yamada KI, Aoki I, Matsumoto KI.
Free Radic Biol Med. 22;143:412-421, 2019.

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice.

Kurihara,K, Homma T, Kobayashi S, Shichiri M, Fujiwara H, Fujii S, Yamada KI, Nakane M, Kawamae K, Fujii J.
J Clin Biochem Nutr. 65(2):1-8, 2019

2-Oxo-histidine-containing dipeptides are functional oxidation products.

Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamada KI, Uchida K.
J Biol Chem. 25;294(4):1279-1289, 2019

2018

Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative.

Araki T, Fuchi Y, Murayama S, Shiraishi R, Oyama T, Aso M, Aoki I, Kobayashi S, Yamada KI, Karasawa S.
Nanomaterials. 2;8(10), 2018

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma T, Shirato T, Akihara R, Kobayashi S, Lee J, Yamada KI, Miyata S, Takahashi M, Fujii J.
Toxicol Lett. 690:6-10, 2018

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells.

Yamamoto K, Yasui H, Bo T, Yamamori T, Hiraoka W, Yamasaki T, Yamada KI, Inanami O.
Appl Magn Reson. 49(8):837-851, 2018

In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging.

Yasukawa K, Shigemi R, Kanbe T, Mutsumoto Y, Oda F, Ichikawa K, Yamada KI, Tun X, Utsumi H.
JAntioxid Redox Signal. 2018

Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice.

Kato N, Sato S, Yamada KI, Ichikawa K.
Appl Magn Reson. 49(8)869-879, 2018

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto S, Matsuoka Y, Yamato M Yamada KI.
J Clin Biochem Nutr. 62(2):132-138, 2018

2017

Detection and inhibition of lipid-derived radicals in low-density lipoprotein.

Ishida Y, Okamoto Y, Matsuoka Y, Tada A, Janprasit J, Yamato M, Morales NP, Yamada KI.
Free Radical Biol. Med. 113,487-493,2017

Lipid radicals cause light-induced retinal degeneration.

Enoki M, Shinto S, Matsuoka Y, Otsuka A, Kaidzu S, Tanito M, Shibata T, Uchida K, Ohira A, Yamato M, Yamada KI.
Chem. Commun. 53,10922-10925,2017

Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T.

Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto K, Kamada T, Yamada KI, Aoki I.
Am J Transl Res. 9(10):4481-4491, 2017.

Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging.

Emoto MC, Matsuoka Y, Yamada KI, Sato-Akaba H, Fujii HG.
Biochem Biophys Res Commun. 2017 Apr 15;485(4):802-806 Epub 2017 Feb 28.

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T, Yamasaki T, Yamada K, Inanami O.
Cancer Lett. 2017 Jan ;390:160-167.

2016

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)

Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada KI, Miyata S, Nakajima O, Fujii J.
Behav Brain Res. 2016 Nov 22;319:219-224.

Fluorescence probes to detect lipid-derived radicals.

Yamada K, Mito F, Matsuoka Y, Ide S, Shikimachi K, Fujiki A, Kusakabe D, Ishida Y, Enoki M, Tada A, Ariyoshi M, Yamasaki T, Yamato M.
Nat Chem Biol. 2016 Aug;12(8):608-13.

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.

Kurahashi T, Lee J, Nabeshima A, Homma T, Kang ES, Saito Y, Yamada S, Nakayama T, Yamada KI, Miyata S, Fujii J.
Arch Biochem Biophys. 604:36-46, 2016.

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma.

Matsuoka Y, Ohkubo K, Yamasaki T, Yamato M, Ohtabu H, Shirouzu T, Fukuzumi S, Yamada K.
RSC Advances. 58(1):16-22, 2016.

TEMPOL increases NAD+ and improves redox imbalance in obese mice.

Yamato M, Kawano K, Yamanaka Y, Saiga M, Yamada KI.
Redox Biol. 8:316-322, 2016.

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats.

Kimura S, Inoguchi T, Yamasaki T, Yamato M, Ide M, Sonoda N, Yamada K, Takayanagi R.
Metabolism. 65(3): 138-145, 2016.

Fluorescence probe for the convenient and sensitive detection of ascorbic acid.

Matsuoka Y, Yamato M, Yamada K.
J. Clin. Biochem. Nutr. 58(1):16-22, 2016.

2015

Brain Contrasting Ability of Blood-Brain-Barrier- Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging.

Matsumoto K, Yamasaki T, Nakamura M, Ueno M, Nakanishi I, Shibata S, Sekita A, Saga T, Kamada T, Yamada K, Aoki I.
Magn Reson Med. DOI: 10.1002/mrm.25918,2015

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress.

Ikeda M, Ide T, Fujino T, Arai S, Saku K, Kakino T, Tyynismaa H, Yamasaki T, Yamada K, Kang D, Suomalainen A, Sunagawa K.
PLoS One. 10(3):e0119687, 2015. doi:10.1371/journal. pone.0119687.

2014

Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis.

Tun X, Yasukawa K, Yamada K.
Free Radic Biol Med. 2014 Sep;74:108-17. doi: 10.1016/j.freeradbiomed.2014.06.020. Epub 2014 Jun 30.

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

Kajer TB, Fairfull-Smith KE, Yamasaki T, Yamada KI, Fu S, Bottle SE, Hawkins CL, Davies MJ.
Free Radic Biol Med. 70:96-105, 2014.

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.

Kurahashi T, Kwon M, Homma T, Saito Y, Lee J, Takahashi M, Yamada KI, Miyata S, Fujii J.
Biochem Biophys Res Commun. 452(1):136-41, 2014.

Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction.

Yamato M, Ishimatsu A, Yamanaka Y, Mine T, Yamada K.
J Clin Biochem Nutr. 55(1):11-14, 2014.

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice.

Ito J, Otsuki N, Zhang X, Konno T, Kurahashi T, Takahashi M, Yamato M, Matsuoka Y, Yamada K, Miyata S, Fujii J.
Life Sci. 95(1):1-8, 2014.

Change in Overhauser Effect-Enhaced MRI Signal in Response to uPA Highly Expressing in Tumor.

Niidome T, Chijiiwa N, Yamasaki T, Yamada K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayama Y
Chem Lett. 43:999-1001, 2014.

Diffusion Studies of Redox-Sensitive Nitroxyl Spin Probes through Bilayer Lipid Membranes using 300 MHz Electron Spin Resonance Spectrometer.

Dhas MK, Utsumi H, Ichikawa K, Yamada K, Hyodo F, Jawahar A, Benial AMF.
Eur J Acad Essays. 1(3):70-75, 2014.

2013

Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents.

Emoto M, Yamada KI, Yamato M, Fujii H.
Neurosci Lett. 2013 May 2 [Epub ahead of print])

2012

Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch.

Matsuoka Y, Yamato M, Yamasaki T, Mito F and Yamada KI.
Free Radic Biol Med. 2012 Dec 1;53(11):2112-8. doi: 10.1016/j.freeradbiomed.2012.09.032. Epub 2012 Sep 28.

The detrimental effect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis.

Yasukawa K, Tokuda H, Tun X, Utsumi H and Yamada KI.
Free Radic Res. 2012 Dec;46(12):1427-36. doi: 10.3109/10715762.2012.732698. Epub 2012 Oct 9.

Synthesis and Utilization of α-Substituted Nitroxides.

Yamasaki T, Mito F, Matsuoka Y, Yamato M and Yamada KI.
(Book Chapter)in Nitroxides – Theory, Experiment and Applications Intech. 2012 Sep 12 [online] doi: 10.5772/39163

Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer.

A. Milton Franklin Benial, M. Kumara Dhas, Ichikawa K, Yamada KI, Hyodo F, Jawahar A. and Utsumi H.
Appl Magn Reson. 2012 Aug 2 [Epub ahead of print]

Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI.

Kosem N, Naganuma T, Ichikawa K, Phumala Morales N, Yasukawa K, Hyodo F, Yamada K, Utsumi H.
Free Radic Biol Med. 2012 Jul 15;53(2):328-36. doi: 10.1016/j.freeradbiomed.2012.04.026. Epub 2012 Apr 30.

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice.

Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada KI, Kinugawa S, Tsutsui H.
Mol Cell Biochem. 2012 Jan;359(1-2):161-7. doi: 10.1007/s11010-011-1010-3. Epub 2011 Aug 18.

2011

Redox Potential of Nitroxides is an Index to Evaluate Superoxide Dismutase Mimic Activity.

Yamasaki T, Matsuoka Y, Mito F, Yamato M, Yamada KI.
Asian J Org Chem. 2013 May 10 (2013 Mar 7 [Epub ahead of print])

A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease.

Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.
Neuromolecular Med. 2013 Jun;15(2):238-51. doi: 10.1007/s12017-012-8214-x. Epub 2013 Jan 5.

Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.

Deguchi H, Yasukawa K, Yamasaki T, Mito F, Kinoshita Y, Naganuma T, Sato S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada KI.
Free Radic Biol Med. 2011 Nov 1;51(9):1799-805. Epub 2011 Aug 18.

A novel ascorbic acid-resistive nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse.

Emoto M, Mito F, Yamasaki T, Yamada KI, Sato-Akaba H, Hirata H, Fujii H.
Free Radic Res. 2011 Nov;45(11-12):1325-32. Epub 2011 Sep 26.

Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model.

Yamato M, Shiba T, Naganuma T, Ichikawa K, Utsumi H, Yamada KI.
Neurochem Int. 2011 Nov;59(6):804-11. Epub 2011 Aug 17.

Oxygen cconcentration dependence of lipid peroxidation and lipid-derived radical generation: Application of profluorescent nitroxide switch.

Mito F, Kitagawa K, Yamasaki T, Shirahama C, Oishi T, Ito Y, Yamato M, Yamada K.
Free Radic Res. 2011 Sep;45(9):1103-10.

In vivo imaging of mitochondrial function in methamphetamine-treated rats.

Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada K.
NeuroImage. 2011 Aug 1;57(3):866-72.

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.

Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S.
Schizophr Res. 2011 Jul;129(2-3):172-82.

Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects.

Yamato M, Shiba T, Ide T, Honda Y, Yamada KI, Tsutsui H.
Hypertens Res. 2011 Jul;34(7):840-5.

Structural concept of nitroxide as a lipid peroxidation inhibitor.

Yamasaki T, Ito Y, Mito F, Kitagawa K, Matsuoka Y, Yamato M, Yamada KI.
J. Org. Chem. 2011 April 18;76(10):4144-8

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.

Mito F, Yamasaki T, Ito Y, Yamato M, Mino H, Sadasue H, Shirahama C, Sakai K, Utsumi H, Yamada KI.
Chem Commun (Camb). 2011 May 7;47(17):5070-2

Structure−reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies.

Yamasaki T, Mito F, Ito Y, Pandian S, Kinoshita Y, Nakano K, Murugesan R, Sakai K, Utsumi H, Yamada K.
J. Org. Chem. 2011 Jan 21;76(2):435-40.